When oral therapy is not feasible, and the strength, dosage form and route of administration of the drug reasonably lend the preparation to the treatment of the condition, A-Methapred sterile powder is indicated for intravenous or intramuscular use in the following conditions:

• Endocrine Disorders

  ? Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance)

  ? Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogs are used)

  ? Preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful

  ? Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected

  ? Congenital adrenal hyperplasia

  ? Hypercalcemia associated with cancer

  ? Nonsuppurative thyroiditis

• Rheumatic Disorders

  As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

  ? Post-traumatic osteoarthritis

  ? Synovitis of osteoarthritis

  ? Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)

  ? Acute and subacute bursitis

  ? Epicondylitis

  ? Acute nonspecific tenosynovitis

  ? Acute gouty arthritis

  ? Psoriatic arthritis

  ? Ankylosing spondylitis

• Collagen Diseases

  During an exacerbation or as maintenance therapy in selected cases of:

  ? Systemic lupus erythematosus

  ? Systemic dermatomyositis (polymyositis)

  ? Acute rheumatic carditis

• Dermatologic Diseases

  ? Pemphigus

  ? Severe erythema multi-forme (Stevens-Johnson syndrome)

  ? Exfoliative dermatitis

  ? Bullous dermatitis herpetiformis

  ? Severe seborrheic dermatitis

  ? Severe psoriasis

  ? Mycosis fungoides

• Allergic States

  Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in:

  ? Bronchial asthma

  ? Contact dermatitis

  ? Atopic dermatitis

  ? Serum sickness

  ? Seasonal or perennial allergic rhinitis

  ? Drug hypersensitivity reactions

  ? Urticarial transfusion reactions

  ? Acute noninfectious laryngeal edema (epinephrine is the drug of first choice)

• Ophthalmic Diseases

  Severe acute and chronic allergic and inflammatory processes involving the eye, such as:

  ? Herpes zoster ophthalmicus

  ? Iritis, iridocyclitis

  ? Chorioretinitis

  ? Diffuse posterior uveitis and choroiditis

  ? Optic neuritis

  ? Sympathetic ophthalmia

  ? Anterior segment inflammation

  ? Allergic conjunctivitis

  ? Allergic corneal marginal ulcers

  ? Keratitis

• Gastrointestinal Diseases

  To tide the patient over a critical period of the disease in:

  ? Ulcerative colitis (systemic therapy)

  ? Regional enteritis (systemic therapy)

• Respiratory Diseases

  ? Symptomatic sarcoidosis

  ? Berylliosis

  ? Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy

  ? Loeffler?s syndrome not manageable by other means

  ? Aspiration pneumonitis

• Hematologic Disorders

  ? Acquired (autoimmune) hemolytic anemia

  ? Idiopathic thrombocytopenic purpura in adults (IV only; IM administration is contraindicated)

  ? Secondary thrombocytopenia in adults

  ? Erythroblastopenia (RBC anemia)

  ? Congenital (erythroid) hypoplastic anemia

• Neoplastic Diseases

  For palliative management of:

  ? Leukemias and lymphomas in adults

  ? Acute leukemia of childhood

• Edematous States

  ? To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus

• Nervous System

  ? Acute exacerbations of multiple sclerosis

• Miscellaneous

  ? Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy

  ? Trichinosis with neurologic or myocardial involvement